Eldercalcitol Osteoporosis treatment

Eldercalcitol Osteoporosis drug treatment shows real promise for reducing fractures of the spine and wrist AND it is not associated with any serious side effects. The drug has been used for the treatment of Osteoporosis in Japan since 2011.

Eldercalcitol Osteoporosis drug is a special form of Vitamin D. There have been a number of scientific studies  published in peer reviewed journals about it.  I summarize a few so you can get a sense of this drugs potential  in the treatment of bone loss.

Scientific Studies: Eldercalcitol Osteporosis drug

In March of 2012 t a study by T. Matsumoto and I Endo from the University of Tokushima Graduate School of Medical Sciences
compared Eldercalcitol with Alfacalcidol. (Both these drugs are analogues of vitamin D. NOTE: An analog, "is a compound having a structure  similar to that of another one, but differing from it in respect of a certain component" . Wikipeida, 2013.)


The study was 'double blind' and involved patients with osteoporosis who were given given once a day oral doses of either Eldercalcitol
or a Alfacalcidol for 3 years.  The researchers found that those receiving the Eldercalctol Osteoporosis drug "reduced vertebral fracture incidence by 26%" and  reduced the incidence of wrist fractures by 71% compared to Alfacalcidol. They found that the drug was well tolerated and was not associated with serious side effects, including hepercalcemia.

To read the complete abstract for this study of Eldercalcitol Osteoporosis drug treatment, copy and paste this url into your browser: http://www.ncbi.nlm.nih.gov/pubmed/22462038


An article from the Research Institute and Practice for Involutional Diseases, Nagano, Japan. showed that "Eldecalcitol normalizes, but does not overly suppress, bone turnover regardless of baseline levels of bone turnover markers.....It  is unlikely that eldecalcitol treatment will increase the risk of severely suppressed bone turnover and therefore  deterioration of bone quality, at least for a treatment duration of 3 years."  This study shows  Eldercalcitol differs from the widely prescribed  bisphosphonates which do suppress bune turnover and seem to result in spontaneous fractures after some years of use. (Italics are mine)

This study can be found at: http://www.ncbi.nlm.nih.gov/pubmed/21902297

Less hypercalcium wiht eldercalcitol.

One of the side effect of some Vitamin D treatments to improve bone density  can be 'hypercalcaemia". too much calcium in the blood. It appears that those taking Eldercalcitol have much less chance of hypercacaemia than those taking alfacalcidol, another form of Vitamin D. 

A study for this side effect showed that  "alfacalcidol, 21.0% and 13.5% of eldecalcitol 0.75 μg/day and alfacalcidol 1.0 μg/day recipients had increased blood calcium,  whereas hypercalcaemia (defined as a serum calcium >2.9 mmol/L) occurred in 0.4% and urolithiasis in 1.3% of eldecalcitol recipients  over 36 months of treatment". This is good news for anyone considering this drug to reverse their bone loss.

See: http://www.ncbi.nlm.nih.gov/pubmed/21902297

Click to  read additional studies about Eldercalcitol Osteoporosis drug tretment.

Now, Eldercalcitol has been in use in Japan since 2011.  I do not know what other countries have approved the drug for those with bone loss.  If you are intereted, I suggest that you ask your health care provider. And since drugs often take different names in different countries, you might want print outs is checmial composition, (1α,25[OH](2)-2β-(3-hydroxypropyloxy)vitamin D(3); ED-71; Edirol®) to show your
health care provider.

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If you have used this drug and want to share your experience, please use the form below.  Thanks in advance